Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET).
نویسندگان
چکیده
Imaging the dopamine D 3 receptor (D 3 R) in humans in vivo has been hampered by the lack of suitable tools. The D 3 R is pharmacologically similar to the dopamine D 2 receptor (D 2 R), and is located in the same brain areas as the D 2 R, albeit at significantly lower density. The signal obtained from a positron emission tomography (PET) study is proportional to the target density (B avail) and the affinity of the PET radioligand for the target (K d). Existing D 2 /D 3
منابع مشابه
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[11C]-(+)-PHNO (4-propyl-9-hydroxynaphthoxazine) is a new agonist radioligand that provides a unique opportunity to measure the high-affinity states of the D2 receptors (D2-high) using positron emission tomography (PET). Here we report on the distribution, displaceablity, specificity and modeling of [11C]-(+)-PHNO and compare it with the well characterized antagonist D2 radioligand, [11C]raclop...
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ورودعنوان ژورنال:
- The international journal of neuropsychopharmacology
دوره 13 3 شماره
صفحات -
تاریخ انتشار 2010